The restaurant is built around fresh, handmade pasta, produced at a table set at the center of the room, with sourcing that runs local, national, and seasonal depending on what's available. The menu rotates, but has included a radiatori pasta coated in basil-pistachio pesto and topped with sesame-seaweed furikake, and a foot-long chicken parm finished with sweet salami compote and Thai chile giardiniera. Cacio e pepe is a standing favorite on the menu, and meatballs and sourdough have developed a following of their own.
Dio Mio also runs a Pasta Club, sending out monthly kits of handmade pasta with sauces, garnishes, a salad, and its focaccia for cooking at home.
Dio Mio has been a Michelin Guide Selected restaurant every year from 2023 through 2026.

