Corn is nixtamalized in-house daily, with heirloom corn from Oaxaca going into fresh tortillas and masa alongside local corn. Seafood comes from the California coast, and produce is pulled from local farmers as well as the restaurant's own Presidio garden. Standouts include a ceviche acapulqueño built on sour oranges and a mini Dungeness crab torta ahogada, alongside a chicken milanesa; the kitchen also sources chocolate from Chiapas and pours artisanal mezcals. Both an a la carte menu and a chef's tasting menu are offered.
The dining room is intimate, with limited seating and a deliberately unhurried pace, and the restaurant also offers private dining with bespoke menus for larger gatherings.
Michelin selected Maria Isabel for its 2026 guide.

