Domilise's started around 1918 as Peter and Sophie Domilise's neighborhood corner bar off Annunciation Street, before Sophie began cooking plate lunches for longshoremen and riverfront workers. Sam Domilise and his wife, Dorothy "Miss Dot" Domilise, took over after World War II, and Miss Dot ran the shop for decades, becoming an Uptown fixture in her own right. Patti "NuNu" Domilise and her sons Josh and Zack carried it forward, and the shop is now on its third and fourth generation of family ownership.
The menu holds to shrimp, oyster, roast beef, and sausage po-boys on Leidenheimer bread, using recipes carried down from Miss Dot's time behind the counter. Several staff members have been there for decades, including a bartender approaching 45 years on the job.
Domilise's closed for an extended stretch only once, evacuating during Hurricane Katrina before reopening later that year to a line stretching down the block. It holds a spot on Eater's Eater 38 and earned a Michelin Bib Gourmand in 2025.
The menu holds to shrimp, oyster, roast beef, and sausage po-boys on Leidenheimer bread, using recipes carried down from Miss Dot's time behind the counter. Several staff members have been there for decades, including a bartender approaching 45 years on the job.
Domilise's closed for an extended stretch only once, evacuating during Hurricane Katrina before reopening later that year to a line stretching down the block. It holds a spot on Eater's Eater 38 and earned a Michelin Bib Gourmand in 2025.